Direct mechanochemical cleavage of functional groups from graphene

Direct mechanochemical cleavage of functional groups from graphene.

Mechanical stress can drive chemical reactions and is unique in that the reaction product can depend on both the magnitude and the direction of the applied force. Indeed, this directionality can drive chemical reactions impossible through conventional means. However, unlike heat- or pressure-driven reactions, mechanical stress is rarely applied isometrically, obscuring how mechanical inputs rel...

Using graphene to protect DNA from cleavage during cellular delivery.

We have proved that functionalized nanoscale graphene oxide can protect oligonucleotides from enzymatic cleavage and efficiently deliver oligonucleotides into cells.

Using graphene to protect DNA from cleavage during cellular deliveryw

Genetic engineering holds great promise and opportunities for medicine and biomedical research. For example, RNA interference (RNAi) and antisense (AS) therapies are potentially powerful candidates for clinical treatments of various ailments, including cancer and AIDS. However, these therapeutic oligonucleotides are easily degraded by cellular enzymes or digested by cellular nucleases. Some mea...

Ring Cleavage of Some Bicylic Compounds Derived from 1,2,4-Triazine

Ring cleavage occurred when 1,2,4-triazino-1,2,4-triazines (3), (4) and (5) were treated with concentrated hydrochloric acid to yield N-substituted triazines (7) and (8). These confirm the given configuration assigned to the isomeric triazinotriazines. 6-Methyl-2-phenyl-7H-oxazolo [3,2-b][1,2,4]-triazin-7-one (9) underwent ring cleavage on treatment with sodium alkoxide to afford 3-alkoxy-1...

Generalized Covering Groups and Direct Limits